@Article{AndRib02a, author = "A. Andreatta and C.C. Ribeiro", title = "Heuristics for the phylogeny problem", journal = "Journal of Heuristics", volume = "8", pages = "429--447", year = "2002", annote = "A phylogeny is an evolutionary tree that relates taxonomic units, based on their similarity over a set of characters. To solve the phylogeny problem means to find a phylogeny with the minimum number of evolutionary steps, i.e. appying the so called parsimony criterion. In this paper, several different heuristic approaches are studied and tested, including a {GRASP}. Three different neighborhood structures have been investigated: the nearest neighborhood interchange, the single step neighborhood, and the subtree pruning and regrafting. The first one is defined by permutations of subtrees around internal branches, while the single step neighborhood removes at each iteration a taxon (i.e. a leaf) and puts it back into another branch of the tree. In the subtree pruning and regrafting, a neighbor is obtained by eliminating an internal node and its three adjacent branches. Then, two pending nodes are joined by a new branch and the still pending subtree is reconnected by its pending node to a branch of the other subtree.", } @techreport{AndRas03a, author = "M. Andronescu and B. Rastegari", title = {{Motif-{GRASP} and {Motif-ILS}: {T}wo new stochastic local search algorithms for motif finding}}, institution = "Computer Science Department, University of British Columbia", address = "Vancouver, Canada", annote = {A motif is a conserved pattern thought to exist in several biosequences such as DNA, RNA, and proteins. Given $N$ biosequences $S_i$, $i=1,2,\ldots,N$ with length $n_i$ and a number $L$, the problem of motif finding consists in finding a sequence $M_i$ of length $L$ for each biosequence such that their similarity grade is maximized. A candidate solution is represented as a set $a_1,a_2,\ldots,a_N$, where $a_k\in [1,n_k-L+1]$, for each $k\in [1,N]$. All candidate solutions correspond to all possible combinations of $a_i$ assignment. Several greedy functions are proposed based on the a weight defined on the starting point of the motif. One of such greedy function is the ratio between the probability of generating a certain subsequence $x$ from the current motif and the probability of generating $x$ from the background. The neighborhood structure used in the local search procedure is a $1$-exchange.}, year = "2003" } @phdthesis{Bro00a, author = "D.C. Brown", title = "Algorithmic methods in genetic mapping", school = "Cornell University", address = "Ithaca, NY, USA", annote = "This thesis is a survey of existing methods for genetic mapping problems and proposed several new algorithms. A {GRASP} has been also investigated. The greedy function is defined on bin length, while the local search first removes from the sample those population members that do not affect on the objective function value. Then, it tries to greedily augment the sample until no member can been removed without increasing the minimum bin size", year = "2000", } @Article{BroVisTan00a, author = "D.G. Brown and T.J. Vision and S.D. Tanksley", title = {{Selecting mapping: {A} discrete optimization approach to select a population subset for use in a high-density genetic mapping project}}, journal = "Genetics", volume = "155", pages = "407--420", year = "2000", annote = "The authors propose a {GRASP} for selecting a population subset for use in a high-density genetic mapping project. At each iteration of the construction phase, they add to the partial solution one among the $r$ unchosen population members which most improve the objective function value. The authors investigated very small sized RCL (i.e. $r=3$ and $r=5$). The implemented local search removes from the current solution some members and greedily includes other members, until no further improving exchange can be done.", } @techreport{FriHorProStrStr03a, title = {The footprint sorting problem}, author = {C. Fried and W. Hordijk and S.J. Prohaska and C.R. Stradler and P.F. Stradler}, institution = {Bioinformatics, Department of Computer Science, University of Leipzig, Germany}, annote = {Phylogenetic footprints are short pieces of no-coding DNA sequence in genes that are conserved between evolutionary distant species. The authors of this paper show that solving the footprint sorting problem requires the solution of a minimum weight vertex feedback set problem. For solving the latter, they use the {GRASP} provided in Festa et al. (2001).}, year = {2003} } @inproceedings{IorTriLiaWal99a, author = "V.I. Iorvik and E. Triantaphyllou and T.W. Liao and S.M. Waly", title = "Predicting muscle fatique via electromyography: {A} comparative study", booktitle = "Proceedings of the 25th International Conference on Computers and Industrial Engineering", city = "New Orleans, LA, USA", month = "March", year = "1999", annote = "The authors present a comparison of some state-of-the-art AI predictive and statistical techniques, including a {GRASP}.", pages = "277--280" } @techreport{KraPelRusTer98a, author = "N. Krasnogor and D.A. Pelta and W. Russo and G. Terrazas", title = "A {GRASP} approach to the protein structure prediction problem", institution = "LIFIA Lab, University of La Plata", address = "La Plata, Argentina", year = "1998", annote = "This paper discusses the applicability of a {GRASP} for solving a special protein folding problem, an important problem in computational biology. The goal is to predict from the molecular sequence of a given protein its particular 3D structure." } @incollection{ReyDicRobWesIglBoeRay03a, author = {A.P. Reynolds and J.L. Dicks and I.N. Roberts and J.J. Wesselink and B. {de la Iglesia} and V. Robert and T. Boekhout and V.J. Rayward-Smith}, title = {Algorithms for identification key generation and optimization with application to yeast identification}, booktitle = {Applications of Evolutionary Computing}, series = {Lecture Notes in Computer Science}, publisher = "Springer-Verlag", volume = {2611}, pages = {107--118}, annote = {For the automated creation of low cost identification keys, several algorithms are described in this paper. One of them applies the greedy randomized strategy of the {GRASP} framework.}, year = {2003} } @techreport{RibVia03a, author = "C.C. Ribeiro and D.S. Vianna", title = {A {GRASP}/{VND} heuristic for the phylogeny problem using a new neighborhood structure}, institution = {Department of Computer Science, Catholic U. of Rio de Janeiro}, address = "Rio de Janeiro, Brazil", annote = {The phylogeny problem consists in finding a phylogeny with the minimum number of evolutionary steps, where a phylogeny is a tree that relates taxonomic units based on their similarity over a set of characters. The authors propose a hybridization of {GRASP} and VND. The greedy criterion is based on insertions of new taxons into a branch of the current partial solution. The local search phase uses a VND strategy and a new neighborhood structure, called $2$-SPR and based on the iterative removing of branches on the cuurent solution.}, year = "2003" }